In a highly connected society, it is easy to be exposed to malicious software, also known as malware, which negatively influences our daily lives. For this reason, NICS Lab has performed a study that uses malware samples extracted from VirusTotal platform in order to analyze how the most popular operating systems today can be affected by such malware. The main findings of this study are as follows: i) ChromeOS has been the only operating system that has stopped all threats from both executable files and documents, ii) Windows remains the preferred operating system by attackers, and iii) after ChromeOS, Linux (Ubuntu) is the system that has performed best against malicious office documents.